Dr. Asmaa Mourad

Anion-Induced Enantioselective Cyclization Catalyzed by Cationic Gold Catalysts

A5 Softcover: 256 Seiten Erscheinungsjahr: 2013 ISBN: 9783895748462
29,80  inkl. MwSt,versandkostenfrei

In this thesis the first highly enantioselective functionalization of terminal alkynes using gold(I) catalysts incorporating optically active counteranions is described.


Cationic gold(I) catalysis was used in a novel asymmetric synthesis of substituted pyrrolidines, 2,3-dihydro-1H-pyrroles, and tetrahydrofurans from 1,4-diynamides, 1,6- diynamides, and 1,4-diynols, respectively. The role of counteranions in these transformations was studied and their employment found to be crucial for high selectivities. Utilizing the newly-developed catalytic system allows an access to the products in near quantitative yields and in good to excellent enantiomeric excesses.